Eric asks Dr. Azza if dogs can eat grapes, and the answer is an absolute no. Dr. Azza explains that grapes can cause acute kidney failure in dogs and that their toxicity is unpredictable, with even a very small amount potentially causing serious harm. All grapes are off-limits, regardless of color or whether they are seedless. If a dog eats a grape, she advises contacting a veterinarian or emergency clinic immediately.